19/04/2021

PhD position in Metabolism and Epigenetics of HIV-1 viral infection (f / m / d)

This job offer has expired


  • ORGANISATION/COMPANY
    Heidelberg University Hospital
  • RESEARCH FIELD
    Biological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    01/05/2021 00:00 - Europe/Brussels
  • LOCATION
    Germany › Heidelberg
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/06/2021

OFFER DESCRIPTION

The research group led by Dr. Marina Lusic studies Nuclear architecture and chromatin organization (epigenetics) in viral infection, with a goal to unravel the molecular basis of HIV-1 integration and latency and exploit these insights to develop novel therapeutic strategies. The candidate will work with experimental models of ex vivo virus infections in primary T cells. The project's aim is to dissect the mechanisms of metabolism-induced epigenetic responses to HIV-1 infection and latency establishment, and to improve the rational design of metabolism/epigenetics-based interventions. In particular, the candidate will assess the cross-talk between the intermediary metabolites and chromatin landscape, including histone modifications and chromatin accessibility in response to productive and latent HIV-1 infection and test compounds that activate pathogen transcription to induce reactivation from the viral latent state. We use state of the art cell biology, genomics and microscopy approaches available in biosafety level 3 laboratories to investigate the molecular basis of HIV-1 integration and latency.

More Information

Selection process

Please send your application including a letter of motivation, curriculum vitae, copies of your certificates and transcripts, as well as addresses of the three referees until 01.05.2021 by email to marina.lusic@med.uni-heidelberg.de and bojana.lucic@med.uni-heidelberg.de

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

  • Master’s Degree/Diploma in biology, biochemistry, medicine, or a related field of the life sciences
  • Willingness to work with pathogenic viruses
  • Basic experience in molecular and cell biology (focus on chromatin), virology is a plus
  • Solid knowledge of statistics and basic coding experience (preferably in R)
  • Excellent English communication skills (written and spoken)
  • Ability to work independently and with other team members as a part of an international team

Work location(s)
1 position(s) available at
Heidelberg University Hospital
Germany
-
Heidelberg
69120
Im Neuenheimer Feld 344

EURAXESS offer ID: 630747

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